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Helix structure mimetics

Stabilization of PPII-helical and α-helical peptides for targeted peptide design

Kurzbeschreibung

For targeting protein-protein-interactions, the design and stabilization of peptide modulators is of great pharmacological interest. Here, two groups of novel compounds stabilizing or inducing either proline-rich PPII-helices or α-helix structures in proteins and peptides are described.

Publikationsnummer

PPII helix mimetic: pending Patent Applications from WO 2008/040332 in USA, Europe and Japan. Alpha helix mimetic: International Patent Application pending (unpublished).

 

Anschrift

  • Campus Berlin-Buch
  • Robert-Rössle-Str. 10
  • 13125 Berlin

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