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Peptide for improved pain management

A claudin-1 derived peptide as a transient opener of the paracellular barrier

Kurzbeschreibung

During the postoperative recovery period adequate pain management - blocking nociception but allowing mobilisation - would be of advantage. Opioids do not affect sensory or motor neurons but are limited to systemic therapy because they cannot cross the paracellular barrier around peripheral nerve fibres when applied locally.
A claudin-1 derived peptide has been developed, which transiently opens the paracellular barrier allowing otherwise not permeable substances to reach peripheral nerve fibres by the paracellular route.

Technologie

Entwicklungsstand

An early preclinical data set comprising data related to immunocytochemistry, pharmacokinetics, neural toxicity, MOA and ADME is available. Shorter leads and modifications with adequate efficacy in vitro are under development.

Vorteile/Nutzen

Improved pain management

Publikationsnummer

A priority claiming EP application has been filed in August 2011.

 

Anschrift

  • Campus Berlin-Buch
  • Robert-Rössle-Str. 10
  • 13125 Berlin

Ansprechpartner

 
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